Scientists are developing a "stay sober" pill which allows you to drink as much as you want while limiting the effects of alcohol on their brains.
In tests for the drug, mice given the drug did not even display signs of getting tipsy, despite being fed enough alcohol to make them stumble and fall over.
The research paves the way for a tablet that stops people embarrassing themelves on nights out.
It could help explain why some drinkers are "cheap dates" who start slurring their words and losing their inhibitions after one glass of wine, while others can knock back glass after glass with few ill effects.
The American and Australian scientists who carried out the research focused on the way alcohol affects glial cells, which make up 90 per cent of the brain.
They play a crucial role in the immune system, helping to fight infections such as meningitis. In the experiment, shutting off this immune response produced a remarkable effect – it stopped the mice who were given alcohol from getting drunk the British Journal of Pharmacology reportedLINK